| Peer-Reviewed

Risk Factors of Recurrence of Febrile Seizures in Children in Southwest China: A Three Year Follow up Study

Received: 8 October 2022     Accepted: 16 November 2022     Published: 21 June 2023
Views:       Downloads:
Abstract

Objectives: Risk factors associated with recurrent febrile convulsions in children in southwest China were the main objective of this study. To summarize the effect of telephone follow-up continuous nursing on preventing recurrence after hyperthermia in emergency children. To study the influencing factors and preventive measures of febrile convulsion recurrence in children. Methods: This study was carried out in the pediatrics department of the Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, which is prospective and longitudinal. Children aged 6 months to 6 years who had febrile convulsions for the first time and were seen between October 2016 and September 2019 were included in the study and followed up for recurrence. From The clinical data of 290 children with febrile convulsion were analyzed retrospectively, and the influencing factors of recurrence were analyzed by single factor analysis. Patients were randomly divided into control group and experimental group with 47 cases in each group. The control group was given routine discharge guidance, and the experimental group was given continuous telephone follow-up nursing. Results: Of the 1728 children, 605 (35.1%) had recurrences and 1123 (64.9%) had single febrile convulsions. The recurrence rate was higher in children <6 months of age (41.3%) than in children ≥6 months of age (24.1%). The recurrence rate was 52.5% in children with a temperature of 38°C at the time of the attack, compared to 17.2% in children with a temperature ≥105°F. There was a significant downward trend in the recurrence rate as the temperature increased. Children with a family history of febrile convulsions (45.5%) were more likely to have a relapse than those without a family history of febrile convulsions (27.8%). Multiple logistic regression analysis showed that younger age at onset, lower temperature at onset, shorter time between fever and onset, and family history of febrile convulsions were risk factors for recurrence of febrile convulsions in children. After nursing, the recurrence rate of children in the experimental group within 0.5 years was significantly lower than that in the control group (4.26% vs21.28%, P<0.05); Compared with the control group, the test group had the highest knowledge knowledge score, and the difference was significant (P<0.05). Conclusion: The main risk factors of recurrent febrile attacks in children are young age of onset, short febrile time before the first febrile attack, low body temperature at onset, and family history of febrile attacks. Age < 3 years old, family history of high fever convulsion, season of onset < 6 months, onset temperature ≥39°C, frequency ≥2, complex onset and duration ≥3 min are all risk factors for recurrence of high fever convulsion. Prevention should be conducted against the above risk factors to avoid recurrence of convulsion.

Published in Journal of Family Medicine and Health Care (Volume 9, Issue 2)
DOI 10.11648/j.jfmhc.20230902.12
Page(s) 34-40
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Febrile Convulsion, Telephone Follow-Up, Continuous Nursing, Recurrence Related Factors

References
[1] Smith DK, Sadler KP, Benedum M (2019). Febrile Seizures: Risks, Evaluation, and Prognosis. Am Fam Physician, 99 (7): 445-450.
[2] Verity CM, Butler NR, Golding J (2018). Febrile convulsions in a national cohort followed up from birth. I-Prevalence and recurrence in the first five years of life. Br Med J, 290 (678): 1307-1312.
[3] Park KM, Hur Y, Kim HY, Ji KH, Hwang TG, Shin KJ, Ha SY, Park J, Kim SE (2014). Initial respons to antiepileptic drugs in patients with newly diagnosed epilepsy. J Clin Neurosci, 1 (6): 923-926.
[4] Karaoğlu P, Yaş U, Polat Aİ, Ayanoğlu M, Hız S (2021). Clinical predictors of drug-resistant epilepsy in children. Turk J Med, 51 (3): 1249-1252.
[5] Mangunatmadja I, Ismael S, Sastroasmoro S, Suyatna FD, van Nieuwenhuizen O, Cornelis van Hu ffelen A (2021). Risk factors predicting intractability in focal epilepsy in children under 3 years of age: A cohort study. Epilepsy Behav, 37 (12): 3213–3217.
[6] Krumholz A, Wiebe S, Gronseth GS, Gloss DS, Sanchez AM, Kabir AA (2021). Evidence-based guideline: management of an unprovoked frst seizure in adults: report of the guideline developmentsubco mmittee of the American Academy of Neurology and the American Epilepsy Society. Epilepsy, 15 (3): 144–152.
[7] Goel D, Agarwal A, Dhanai JS, Semval VD, Mehrotra V, Saxena V, Maithili B (2019). Comprehensive rural epilepsy surveillance programme in Uttarakhand state of India. Neurol India, 57 (3): 355-362.
[8] Andreasson AC, Sigurdsson GV, Pegenius G, Thordstein M, Hallböök T (2020). Cortical excitability measured with transcranial magnetic stimulation in children with epilepsy before and after antiepileptic drugs. Dev Med Child Neurol, 62 (7): 793-798.
[9] Steering Committee on Quality Improvement and Management, Subcommittee on Febrile Seizures American Academy of Pediatrics (2008). Febrile seizures: clinical practice guideline for the long-term management of the child with simple febrile seizures. Pediatrics, 121 (6): 1281-1286.
[10] Glauser T, Ben-Menachem E, Bourgeois B, Cnaan A, Guerreiro C, Kälviäinen R, Mattson R, French JA, Perucca E, Tomson T (2013). ILAE Subcommission on AED Guidelines. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia, 54 (3): 551-563.
[11] Lee SK. Diagnosis and Treatment of Status Epilepticus (2020). J Epilepsy Res, 10 (2): 45-54.
[12] Kourbeti IS, Jacobs AV, Koslow M, Karabetsos D, Holzman RS (2007). Risk factors associated with postcraniotomy meningitis. Neurosurgery, 60 (2): 317-325.
[13] Sartori S, Nosadini M, Tessarin G, Boniver C, Frigo AC, Toldo I, Bressan S, Da Dalt L (2019). First-ever convulsive seizures in children presenting to the emergency department: risk factors for seizure recurrence and diagnosis of epilepsy. Seizure, 61 (1): 82-90.
[14] Ma SJ, Xiong YQ, Jiang LN, Chen Q (2015). Risk of febrile seizure after Measles-Mumps-Rubella-Varicella: A systematic review and meta-analysis. Vaccine, 33 (31): 3636-3649.
[15] Kwak BO, Kim K, Kim SN, Lee R (2017). Relationship between iron deficiency anemia and febrile se izures in children: A systematic review and meta-analysis. Seizure, 52 (5): 27-36.
[16] Kubota J, Higurashi N, Hirano D, Okabe S, Yamauchi K, Kimura R, Numata H, Suzuki T, Kakegawa D, Ito A, Hamano SI (2021). Body temperature predicts recurrent febrile seizures in the same febrile ill ness. Brain Dev, 43 (7): 768-774.
[17] Chung B, Wat LC, Wong V (2006). Febrile seizures in southern Chinese children: incidence and recur rence. Pediatr Neurol, 34 (2): 121-126.
[18] Hughes DM, Bonnett LJ, Marson AG, García-Fiñana M (2019). Identifying patients who will not reachi eve remission after breakthrough seizures. Epilepsia, 60 (4): 774-782.
Cite This Article
  • APA Style

    Jian Wang, Can Zhang, Juan Yang, Caixia Zhao, Kun Zhang. (2023). Risk Factors of Recurrence of Febrile Seizures in Children in Southwest China: A Three Year Follow up Study. Journal of Family Medicine and Health Care, 9(2), 34-40. https://doi.org/10.11648/j.jfmhc.20230902.12

    Copy | Download

    ACS Style

    Jian Wang; Can Zhang; Juan Yang; Caixia Zhao; Kun Zhang. Risk Factors of Recurrence of Febrile Seizures in Children in Southwest China: A Three Year Follow up Study. J. Fam. Med. Health Care 2023, 9(2), 34-40. doi: 10.11648/j.jfmhc.20230902.12

    Copy | Download

    AMA Style

    Jian Wang, Can Zhang, Juan Yang, Caixia Zhao, Kun Zhang. Risk Factors of Recurrence of Febrile Seizures in Children in Southwest China: A Three Year Follow up Study. J Fam Med Health Care. 2023;9(2):34-40. doi: 10.11648/j.jfmhc.20230902.12

    Copy | Download

  • @article{10.11648/j.jfmhc.20230902.12,
      author = {Jian Wang and Can Zhang and Juan Yang and Caixia Zhao and Kun Zhang},
      title = {Risk Factors of Recurrence of Febrile Seizures in Children in Southwest China: A Three Year Follow up Study},
      journal = {Journal of Family Medicine and Health Care},
      volume = {9},
      number = {2},
      pages = {34-40},
      doi = {10.11648/j.jfmhc.20230902.12},
      url = {https://doi.org/10.11648/j.jfmhc.20230902.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfmhc.20230902.12},
      abstract = {Objectives: Risk factors associated with recurrent febrile convulsions in children in southwest China were the main objective of this study. To summarize the effect of telephone follow-up continuous nursing on preventing recurrence after hyperthermia in emergency children. To study the influencing factors and preventive measures of febrile convulsion recurrence in children. Methods: This study was carried out in the pediatrics department of the Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, which is prospective and longitudinal. Children aged 6 months to 6 years who had febrile convulsions for the first time and were seen between October 2016 and September 2019 were included in the study and followed up for recurrence. From The clinical data of 290 children with febrile convulsion were analyzed retrospectively, and the influencing factors of recurrence were analyzed by single factor analysis. Patients were randomly divided into control group and experimental group with 47 cases in each group. The control group was given routine discharge guidance, and the experimental group was given continuous telephone follow-up nursing. Results: Of the 1728 children, 605 (35.1%) had recurrences and 1123 (64.9%) had single febrile convulsions. The recurrence rate was higher in children PPConclusion: The main risk factors of recurrent febrile attacks in children are young age of onset, short febrile time before the first febrile attack, low body temperature at onset, and family history of febrile attacks. Age < 3 years old, family history of high fever convulsion, season of onset < 6 months, onset temperature ≥39°C, frequency ≥2, complex onset and duration ≥3 min are all risk factors for recurrence of high fever convulsion. Prevention should be conducted against the above risk factors to avoid recurrence of convulsion.},
     year = {2023}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Risk Factors of Recurrence of Febrile Seizures in Children in Southwest China: A Three Year Follow up Study
    AU  - Jian Wang
    AU  - Can Zhang
    AU  - Juan Yang
    AU  - Caixia Zhao
    AU  - Kun Zhang
    Y1  - 2023/06/21
    PY  - 2023
    N1  - https://doi.org/10.11648/j.jfmhc.20230902.12
    DO  - 10.11648/j.jfmhc.20230902.12
    T2  - Journal of Family Medicine and Health Care
    JF  - Journal of Family Medicine and Health Care
    JO  - Journal of Family Medicine and Health Care
    SP  - 34
    EP  - 40
    PB  - Science Publishing Group
    SN  - 2469-8342
    UR  - https://doi.org/10.11648/j.jfmhc.20230902.12
    AB  - Objectives: Risk factors associated with recurrent febrile convulsions in children in southwest China were the main objective of this study. To summarize the effect of telephone follow-up continuous nursing on preventing recurrence after hyperthermia in emergency children. To study the influencing factors and preventive measures of febrile convulsion recurrence in children. Methods: This study was carried out in the pediatrics department of the Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, which is prospective and longitudinal. Children aged 6 months to 6 years who had febrile convulsions for the first time and were seen between October 2016 and September 2019 were included in the study and followed up for recurrence. From The clinical data of 290 children with febrile convulsion were analyzed retrospectively, and the influencing factors of recurrence were analyzed by single factor analysis. Patients were randomly divided into control group and experimental group with 47 cases in each group. The control group was given routine discharge guidance, and the experimental group was given continuous telephone follow-up nursing. Results: Of the 1728 children, 605 (35.1%) had recurrences and 1123 (64.9%) had single febrile convulsions. The recurrence rate was higher in children PPConclusion: The main risk factors of recurrent febrile attacks in children are young age of onset, short febrile time before the first febrile attack, low body temperature at onset, and family history of febrile attacks. Age < 3 years old, family history of high fever convulsion, season of onset < 6 months, onset temperature ≥39°C, frequency ≥2, complex onset and duration ≥3 min are all risk factors for recurrence of high fever convulsion. Prevention should be conducted against the above risk factors to avoid recurrence of convulsion.
    VL  - 9
    IS  - 2
    ER  - 

    Copy | Download

Author Information
  • The First Clinical Medical College, Yunnan University of Traditional Chinese Medicine, Kunming, China

  • The First Clinical Medical College, Yunnan University of Traditional Chinese Medicine, Kunming, China

  • The First Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing, China

  • The First Clinical Medical College, Yunnan University of Traditional Chinese Medicine, Kunming, China

  • The First Clinical Medical College, Yunnan University of Traditional Chinese Medicine, Kunming, China

  • Sections