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Role of Endocrine System and Hypothalamic Neuropeptides in Hyperphagia Associated Obesity

Received: 3 January 2021     Accepted: 14 January 2021     Published: 10 March 2021
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Abstract

Activities occurring in an animal’s body are performed and regulated via certain chemicals. These chemical on the basis of multiple factors are divided into various classes. Hormones forma major class of such chemicals. Hormones are integral part of animal’s body that are involved in the mediation of a variety of vital functions. Hormonal secretions are precisely regulated in order to mediate relevant function as needed. They are important maintainers of a variety of homeostatic mechanisms including food intake, digestion, absorption and utilization. Like all other parts of animal’s body, adipose tissue is also under the influence of chemical messengers. Some of the endocrine messengers are Leptin, Insulin and Ghrelin hormone while neural chemicals include orexigenic hypothalamic neuropeptides (like Neuropeptide Y). While performing normal assigned function these chemical substances strive to maintain a balance between body energy need and energy intake. If concentration or functionality of any of them is disturbed due to certain change for sufficient time period then they fail to perform their duty resulting gradual increase in body mass index. Deficiency or hypersecretion, structural deformity and functional impairment are some of the aspects that contribute towards hormonal abnormalities. Present review is based on a concise discussion about obesogenic role of Leptin, Insulin and Ghrelin hormones and hypothalamic neuropeptides.

Published in Journal of Family Medicine and Health Care (Volume 7, Issue 1)
DOI 10.11648/j.jfmhc.20210701.13
Page(s) 14-18
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Hyperphagia, Leptin, Insulin, Ghrelin, Adipocity, Endocrine Hormones, Hypothalamic Neuropeptides

References
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  • APA Style

    Mubashir Abbas, Abdul Rehman, Zulfia Hussain, Junaid Ali Khan. (2021). Role of Endocrine System and Hypothalamic Neuropeptides in Hyperphagia Associated Obesity. Journal of Family Medicine and Health Care, 7(1), 14-18. https://doi.org/10.11648/j.jfmhc.20210701.13

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    ACS Style

    Mubashir Abbas; Abdul Rehman; Zulfia Hussain; Junaid Ali Khan. Role of Endocrine System and Hypothalamic Neuropeptides in Hyperphagia Associated Obesity. J. Fam. Med. Health Care 2021, 7(1), 14-18. doi: 10.11648/j.jfmhc.20210701.13

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    AMA Style

    Mubashir Abbas, Abdul Rehman, Zulfia Hussain, Junaid Ali Khan. Role of Endocrine System and Hypothalamic Neuropeptides in Hyperphagia Associated Obesity. J Fam Med Health Care. 2021;7(1):14-18. doi: 10.11648/j.jfmhc.20210701.13

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  • @article{10.11648/j.jfmhc.20210701.13,
      author = {Mubashir Abbas and Abdul Rehman and Zulfia Hussain and Junaid Ali Khan},
      title = {Role of Endocrine System and Hypothalamic Neuropeptides in Hyperphagia Associated Obesity},
      journal = {Journal of Family Medicine and Health Care},
      volume = {7},
      number = {1},
      pages = {14-18},
      doi = {10.11648/j.jfmhc.20210701.13},
      url = {https://doi.org/10.11648/j.jfmhc.20210701.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfmhc.20210701.13},
      abstract = {Activities occurring in an animal’s body are performed and regulated via certain chemicals. These chemical on the basis of multiple factors are divided into various classes. Hormones forma major class of such chemicals. Hormones are integral part of animal’s body that are involved in the mediation of a variety of vital functions. Hormonal secretions are precisely regulated in order to mediate relevant function as needed. They are important maintainers of a variety of homeostatic mechanisms including food intake, digestion, absorption and utilization. Like all other parts of animal’s body, adipose tissue is also under the influence of chemical messengers. Some of the endocrine messengers are Leptin, Insulin and Ghrelin hormone while neural chemicals include orexigenic hypothalamic neuropeptides (like Neuropeptide Y). While performing normal assigned function these chemical substances strive to maintain a balance between body energy need and energy intake. If concentration or functionality of any of them is disturbed due to certain change for sufficient time period then they fail to perform their duty resulting gradual increase in body mass index. Deficiency or hypersecretion, structural deformity and functional impairment are some of the aspects that contribute towards hormonal abnormalities. Present review is based on a concise discussion about obesogenic role of Leptin, Insulin and Ghrelin hormones and hypothalamic neuropeptides.},
     year = {2021}
    }
    

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    AU  - Mubashir Abbas
    AU  - Abdul Rehman
    AU  - Zulfia Hussain
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    DO  - 10.11648/j.jfmhc.20210701.13
    T2  - Journal of Family Medicine and Health Care
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    UR  - https://doi.org/10.11648/j.jfmhc.20210701.13
    AB  - Activities occurring in an animal’s body are performed and regulated via certain chemicals. These chemical on the basis of multiple factors are divided into various classes. Hormones forma major class of such chemicals. Hormones are integral part of animal’s body that are involved in the mediation of a variety of vital functions. Hormonal secretions are precisely regulated in order to mediate relevant function as needed. They are important maintainers of a variety of homeostatic mechanisms including food intake, digestion, absorption and utilization. Like all other parts of animal’s body, adipose tissue is also under the influence of chemical messengers. Some of the endocrine messengers are Leptin, Insulin and Ghrelin hormone while neural chemicals include orexigenic hypothalamic neuropeptides (like Neuropeptide Y). While performing normal assigned function these chemical substances strive to maintain a balance between body energy need and energy intake. If concentration or functionality of any of them is disturbed due to certain change for sufficient time period then they fail to perform their duty resulting gradual increase in body mass index. Deficiency or hypersecretion, structural deformity and functional impairment are some of the aspects that contribute towards hormonal abnormalities. Present review is based on a concise discussion about obesogenic role of Leptin, Insulin and Ghrelin hormones and hypothalamic neuropeptides.
    VL  - 7
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Author Information
  • Institute of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan

  • Institute of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan

  • Institute of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan

  • Institute of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan

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